Abortive Spontaneous Egg Activation: A Limiting Factor For Reproductive Outcome in Mammals
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چکیده
Most of the mammalian species possess asynchronous ovary that exhibit different stages of follicles. During final stages of folliculogenesis, mammalian ovary ensures the generation of competent oocytes required for fertilization and embryonic development. To achieve this goal, large number of incompetent or defective germ cells (>99%) are eliminated from ovary through follicular atresia via apoptosis. At the time of puberty, limited number of germ cells are available in the ovary (<1%), which are culminated into oogonia and then primary oocytes [1]. These primary oocytes are arrested at diplotene stage until pituitary gonadotropin surge at the time of puberty [2]. Gonadotropins trigger meiotic resumption from diplotene arrest and these oocytes progresses to metaphase-II (M-II) stage just prior to ovulation [2,3].
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تاریخ انتشار 2016